Keywords
Bullous pemphigoid
DPP4 inhibitors
Categories
How to Cite
Abstract
Bullous pemphigoid is a clinical entity that has also been described as an adverse effect associated with the use of certain medications. It is essential to perform a thorough differential diagnosis and to establish the possible etiologies in order to initiate appropriate treatment and achieve resolution of the clinical condition. Its potential association with neoplastic processes has also been investigated; however, to date, no conclusive evidence exists beyond that derived from observational studies and systematic reviews. In cases of drug-induced bullous pemphigoid, the response to corticosteroid therapy is usually favorable. In cases of resistance, antibodies may be employed, preferably over immunosuppressive therapy. We present an updated review of the literature, illustrated by a clinical case in which more than one pharmacological agent may have been implicated, including immunotherapy based on an anti–PD-1 monoclonal antibody and an oral antidiabetic agent acting as a dipeptidyl peptidase-4 inhibitor. Early recognition is important with regard to the prognosis of toxicity.
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Copyright (c) 2026 Jorge del Río Fernández, Verónica Velasco Durántez, Teresa González de la Hera, Adán Rodríguez González, Elena Sánchez Romero, Esmeralda Mateo Álvarez, Daniel Ruiz Sánchez, Virginia Galeazzi Martínez