Abstract
Celiac disease (CD) is an autoimmune disorder triggered by gluten ingestion in genetically predisposed individuals, marked by inflammation and the production of anti-tissue transglutaminase antibodies. Although CD patients often have lower body mass indexes and LDL levels, systemic inflammation can lead to endothelial dysfunction and accelerated atherosclerosis, potentially increasing the risk of coronary artery disease (CAD). We present a case of a 46-year-old female with CD who developed multivessel CAD, ultimately requiring coronary artery bypass grafting. This case highlights the significant cardiovascular risk associated with CD, suggesting that inflammation and genetic factors may contribute to atherosclerosis. While the precise mechanisms remain unclear, the findings underscore the need for vigilant cardiovascular monitoring in CD patients and further research to explore the impact of gluten-free diets on cardiovascular health.
References
Dore MP, Mereu S, Saba PS, Portoghese M, Pes GM. Celiac Disease and Cardiovascular Risk: A Retrospective Case-Control Study. J Clin Med. 2023;12(6):2087. doi:10.3390/jcm12062087. PMID: 36983090; PMCID: PMC10051110.
Wang Y, Chen B, Ciaccio EJ, Jneid H, Virani SS, Lavie CJ, Lebovits J, Green PH, Krittanawong C. Celiac Disease and the Risk of Cardiovascular Diseases. Int J Mol Sci. 2023;24(18):9974. doi:10.3390/ijms24129974.
Conroy M, Allen N, Lacey B, et al. Association between coeliac disease and cardiovascular disease: prospective analysis of UK Biobank data. BMJ Med. 2023;2. doi:10.1136/bmjmed-2022-000371.
Gajulapalli RD, Pattanshetty DJ. Risk of coronary artery disease in celiac disease population. Saudi J Gastroenterol. 2017;23(4):253-258. doi:10.4103/sjg.SJG_616_16. PMID: 28721980; PMCID: PMC5539680.
Haider MB, Naylor P, Das A, Haider SM, Ehrinpreis MN. Celiac Disease Patients With Coronary Artery Disease: A Nationwide Population-Based Study. Cureus. 2022;14(6). doi:10.7759/cureus.26151. PMID: 35891813; PMCID: PMC9303833.
Ludvigsson JF, James S, Askling J, Stenestrand U, Ingelsson E, Hemminki K. Nationwide cohort study of risk of ischemic heart disease in patients with celiac disease. Circulation. 2011;123(5):483-490. doi:10.1161/CIRCULATIONAHA.110.965624.
Emilsson L, Andersson B, Elfström P, Green PH, Ludvigsson JF. Risk of idiopathic dilated cardiomyopathy in 29 000 patients with celiac disease. J Am Heart Assoc. 2011;1(4). doi:10.1161/JAHA.112.001594.
Rubio-Tapia A, Ludvigsson JF, Brantner TL, Murray JA, Everhart JE. The prevalence of celiac disease in the United States. Am J Gastroenterol. 2009;104(6):1584-1592. doi:10.1038/ajg.2009.10.
Riddle MS, Murray JA, Porter CK. The incidence and risk of celiac disease in a healthy US adult population. Am J Gastroenterol. 2011;106(5):881-887. doi:10.1038/ajg.2011.21.
Zanini B, Baschè R, Ferraresi A, Ricci C, Lanzarotto F, Villanacci V. Factors that contribute to hyperhomocysteinemia in celiac patients: A prospective study. World J Gastroenterol. 2012;18(38):5324-5331. doi:10.3748/wjg.v18.i38.5324
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Copyright (c) 2024 Jose Fernando Vargas-Ledo, Maria Eugenia Torres-Perez, Mario Alejandro Trujillo-Acosta, Monica Olvera-Lopez