Abstract
Obesity is a public health problem worldwide; the World Health Organization defines obesity as an abnormal or excessive accumulation of fat in adipose tissue that is detrimental to health associated with an increased risk of metabolic diseases. This disease is the consequence of a complex interaction between genetic, environmental and psychological factors. Now we know much better some of the genetic factors that influence obesity and the endocrine and metabolic alterations that it produces, however, it is clear that the obesity epidemic today has multiple etiologies. Environmental factors play a fundamental role in obesity, especially the decrease in physical activity due to technological advances and the transition towards diets rich in saturated fats and sugars.
References
Arroyo-Johnson, C., and Mincey, K. D. (2016). Obesity Epidemiology Worldwide. Gastroenterology Clinics of North America, 45(4), 571–579. doi.org/10.1016/j.gtc.2016.07.012
Singh, S., Dulai, P. S., Zarrinpar, A., Ramamoorthy, S., and Sandborn, W. J. (2017). Obesity in IBD: Epidemiology, pathogenesis, disease course and treatment outcomes. Nature Reviews Gastroenterology and Hepatology, 14(2), 110–121. doi.org/10.1038/nrgastro.2016.181
Chooi, Y. C., Ding, C., and Magkos, F. (2019). The epidemiology of obesity. Metabolism, 92, 6–10. doi.org/10.1016/j.metabol.2018.09.005
González Jiménez, E. (2013). Obesidad: Análisis etiopatogénico y fisiopatológico. Endocrinología y Nutrición, 60(1), 17–24. doi.org/10.1016/j.endonu.2012.03.006
Chiurazzi, M., Cozzolino, M., Orsini, R. C., Di Maro, M., Di Minno, M. N. D., and Colantuoni, A. (2020). Impact of Genetic Variations and Epigenetic Mechanisms on the Risk of Obesity. International Journal of Molecular Sciences, 21(23), 9035. doi.org/10.3390/ijms21239035
Chiurazzi, M., Di Maro, M., Cozzolino, M., and Colantuoni, A. (2020). Mitochondrial Dynamics and Microglia as New Targets in Metabolism Regulation. International Journal of Molecular Sciences, 21(10), 3450. doi.org/10.3390/ijms21103450
Kerns, J., and Fisher, M. (2020). Epidemiology, pathophysiology and etiology of obesity in children and adolescents. Current Problems in Pediatric and Adolescent Health Care, 50(9), 100869. doi.org/10.1016/j.cppeds.2020.100869
Ramos-Molina, B., Martin, M. G., and Lindberg, I. (2016). PCSK1 Variants and Human Obesity. En Progress in Molecular Biology and Translational Science (Vol. 140, pp. 47–74). Elsevier. doi.org/10.1016/bs.pmbts.2015.12.001
Obri, A., Serra, D., Herrero, L., and Mera, P. (2020). The role of epigenetics in the development of obesity. Biochemical Pharmacology, 177, 113973. doi.org/10.1016/j.bcp.2020.113973
Persky, S., Goldring, M. R., El-Toukhy, S., Ferrer, R. A., and Hollister, B. (2019). Parental Defensiveness about Multifactorial Genomic and Environmental Causes of Children’s Obesity Risk. Childhood Obesity, 15(5), 289–297. doi.org/10.1089/chi.2018.0315
Newton, S., Braithwaite, D., and Akinyemiju, T. F. (2017). Socio-economic status over the life course and obesity: Systematic review and meta-analysis. PLOS ONE, 12(5), e0177151. doi.org/10.1371/journal.pone.0177151
Nicolaidis, S. (2019). Environment and obesity. Metabolism, 100, 153942. doi.org/10.1016/j.metabol.2019.07.006
Singhal, A. (2020). Obesity in Toddlers and Young Children: Causes and Consequences. En M. M. Black, A. Singhal, and C. H. Hillman (Eds.), Nestlé Nutrition Institute Workshop Series (Vol. 95, pp. 1–11). S. Karger AG. doi.org/10.1159/000511510
Katare, B., and Beatty, T. K. M. (2018). Do environmental factors drive obesity? Evidence from international graduate students. Health Economics, 27(10), 1567–1593. doi.org/10.1002/hec.3789
Avery, A., Anderson, C., and McCullough, F. (2017). Associations between children’s diet quality and watching television during meal or snack consumption: A systematic review. Maternal and Child Nutrition, 13(4). doi.org/10.1111/mcn.12428
Archer, E., Lavie, C. J., and Hill, J. O. (2018). The Contributions of ‘Diet’, ‘Genes’, and Physical Activity to the Etiology of Obesity: Contrary Evidence and Consilience. Progress in Cardiovascular Diseases, 61(2), 89–102. doi.org/10.1016/j.pcad.2018.06.002
Albuquerque, D., Nóbrega, C., Manco, L., and Padez, C. (2017). The contribution of genetics and environment to obesity. British Medical Bulletin, 123(1), 159–173. doi.org/10.1093/bmb/ldx022
Heianza, Y., and Qi, L. (2019). Impact of Genes and Environment on Obesity and Cardiovascular Disease. Endocrinology, 160(1), 81–100. doi.org/10.1210/en.2018-00591
Engin, A. (2017). The Definition and Prevalence of Obesity and Metabolic Syndrome. En A. B. Engin and A. Engin (Eds.), Obesity and Lipotoxicity (Vol. 960, pp. 1–17). Springer International Publishing. doi.org/10.1007/978-3-319-48382-5_1
Ling, C., and Rönn, T. (2019). Epigenetics in Human Obesity and Type 2 Diabetes. Cell Metabolism, 29(5), 1028–1044. doi.org/10.1016/j.cmet.2019.03.009
Herle, M., Smith, A. D., Kininmonth, A., and Llewellyn, C. (2020). The Role of Eating Behaviours in Genetic Susceptibility to Obesity. Current Obesity Reports, 9(4), 512–521. doi.org/10.1007/s13679-020-00402-0
Parise, I. (2020). The built environment and obesity: You are where you live. Australian Journal of General Practice, 49(4), 226–230. doi.org/10.31128/AJGP-10-19-5102
Di Ciaula, A., and Portincasa, P. (2019). Diet and Contaminants: Driving the Rise to Obesity Epidemics? Current Medicinal Chemistry, 26(19), 3471–3482. doi.org/10.2174/0929867324666170518095736
Squalli, J. (2017). The environmental impact of obesity: Longitudinal evidence from the United States. Public Health, 149, 89–98. doi.org/10.1016/j.puhe.2017.04.016
Gérard, P. (2017). Gut Microbiome and Obesity. How to Prove Causality? Annals of the American Thoracic Society, 14(Supplement_5), S354–S356. doi.org/10.1513/AnnalsATS.201702-117AW
Endalifer, M. L., and Diress, G. (2020). Epidemiology, Predisposing Factors, Biomarkers, and Prevention Mechanism of Obesity: A Systematic Review. Journal of Obesity, 2020, 1–8. doi.org/10.1155/2020/6134362
Scudiero, O., Pero, R., Ranieri, A., Terracciano, D., Fimiani, F., Cesaro, A., Gentile, L., Leggiero, E., Laneri, S., Moscarella, E., Mazzaccara, C., Frisso, G., D’Alicandro, G., Limongelli, G., Pastore, L., Calabrò, P., and Lombardo, B. (2020). Childhood obesity: An overview of laboratory medicine, exercise and microbiome. Clinical Chemistry and Laboratory Medicine (CCLM), 58(9), 1385–1406. doi.org/10.1515/cclm-2019-0789
Amabebe, E., Robert, F. O., Agbalalah, T., and Orubu, E. S. F. (2020). Microbial dysbiosis-induced obesity: Role of gut microbiota in homoeostasis of energy metabolism. British Journal of Nutrition, 123(10), 1127–1137. doi.org/10.1017/S0007114520000380
Santos-Marcos, J. A., Perez-Jimenez, F., and Camargo, A. (2019). The role of diet and intestinal microbiota in the development of metabolic syndrome. The Journal of Nutritional Biochemistry, 70, 1–27. doi.org/10.1016/j.jnutbio.2019.03.017
Noriea, A. H., Patel, F. N., Werner, D. A., and Peek, M. E. (2018). A Narrative Review of Physician Perspectives Regarding the Social and Environmental Determinants of Obesity. Current Diabetes Reports, 18(5), 24. doi.org/10.1007/s11892-018-0990-8
De Lorenzo, A., Romano, L., Di Renzo, L., Di Lorenzo, N., Cenname, G., and Gualtieri, P. (2020). Obesity: A preventable, treatable, but relapsing disease. Nutrition, 71, 110615. doi.org/10.1016/j.nut.2019.110615
Goossens, G. H. (2017). The Metabolic Phenotype in Obesity: Fat Mass, Body Fat Distribution, and Adipose Tissue Function. Obesity Facts, 10(3), 207–215. doi.org/10.1159/000471488
Tsatsoulis, A., and Paschou, S. A. (2020). Metabolically Healthy Obesity: Criteria, Epidemiology, Controversies, and Consequences. Current Obesity Reports, 9(2), 109–120. doi.org/10.1007/s13679-020-00375-0
Berthoud, H.-R., and Klein, S. (2017). Advances in Obesity: Causes, Consequences, and Therapy. Gastroenterology, 152(7), 1635–1637. doi.org/10.1053/j.gastro.2017.03.045
Vishvanath, L., and Gupta, R. K. (2019). Contribution of adipogenesis to healthy adipose tissue expansion in obesity. Journal of Clinical Investigation, 129(10), 4022–4031.doi.org/10.1172/JCI129191
Antonopoulos, A. S., and Tousoulis, D. (2017). The molecular mechanisms of obesity paradox. Cardiovascular Research, 113(9), 1074–1086. doi.org/10.1093/cvr/cvx106
Franks, P. W., and Atabaki-Pasdar, N. (2017). Causal inference in obesity research. Journal of Internal Medicine, 281(3), 222–232. doi.org/10.1111/joim.12577Gadde, K. M., Martin, C. K., Berthoud, H.-R., and Heymsfield, S. B. (2018). Obesity. Journal of the American College of Cardiology, 71(1), 69–84. doi.org/10.1016/j.jacc.2017.11.011
Fruhn SM. Obesity: Risk Factors, complications, and strategies for sustainablelong-term weight management. JAANP 2017;29:S3-S14.
De Lorenzo, A., Gratteri, S., Gualtieri, P., Cammarano, A., Bertucci, P., and Di Renzo, L. (2019). Why primary obesity is a disease? Journal of Translational Medicine, 17(1), 169. doi.org/10.1186/s12967-019-1919-y.
Meldrum, D. R., Morris, M. A., and Gambone, J. C. (2017). Obesity pandemic: Causes, consequences, and solutions—but do we have the will? Fertility and Sterility, 107(4), 833–839. doi.org/10.1016/j.fertnstert.2017.02.104
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Copyright (c) 2024 Diego Melo-Orta